What is Genome Sequencing and Why it is an Essential Part of Genealogy Tree?

Genome

Genealogy looks for specific variants in a relatively tiny fraction across your family heritage — usually, less than 1% of the genome’s A’s, T’s, G’s, and C’s. It’s an effective method for identifying variants; however, it requires a pre-defined list of variants to search for, which limits analysis to those on the list. If you have a variant that is not on this list, it will not be picked up. Further analysis of genotyping data is unable to extract genetic variants from outside of the pre-defined list. For example, me and 23, a popular test that utilizes genotyping technology, looks at less than half of 1% of your genome. While there are thousands of mutations in the BRCA genes, 23 and Me only picks up three of these mutations.

With so many genealogy websites in the market today, it’s difficult to tell what exactly you’re getting. The reality is, not all tests are created equal, but what exactly are the differences?

There are basically two different technologies that are used in popular genetic products. One is genotyping, the other sequencing. Within sequencing, there is Whole Exome Sequencing and Whole Genome Sequencing. Each method has a different approach to looking at genes and also deals with a different amount of genes. Let’s dive in.

Whole Exome Sequencing (WES)

Whole Exome Sequencing (WES) analyzes the exome, the portion of the genome consisting entirely of exomes, which are the protein-coding portions of the genome. At presently, it covers about 20,000 protein-coding genes, with research unlocking more every year. This method is cost-efficient and more robust than genotyping; however, WES still only analyzes less than 2% of the entire genome, leaving an extraordinary wealth of relevant information out of the picture. Whole Exome Sequencing (WES) analyzes the exome, the portion of the genome consisting entirely of exons, which are the protein-coding portions of the genome. At presently, it covers about 20,000 protein-coding genes, with research unlocking more every year. This method is cost-efficient and more robust than genotyping; however, WES still only analyzes less than 2% of the entire genome, leaving an extraordinary wealth of relevant information out of the picture.

Why geneology4u?

Geneology4u website has a mission is to give millions of people access to their genomes and support them making better decisions for their health. It’s that mission that pushes us to keep looking for ways to drive down the price. While, for now, it’s still more expensive than other less comprehensive testing technologies, Whole Genome Sequencing is an invaluable investment for your health management — not just today, but for the rest of your life. enroll geneology4u now.

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